¿What are Mesenchymal Stem Cells?

Multipotent stromal cells, usually known as Mesenchymal Stem Cells (MSC), are cells with differentiation and proliferation capacity, extracted from tissues like the umbilical cord, bone marrow (Bone Marrow Stem Cells, BMSC), and adipose tissue (Adipose Stem Cells, ASC).

Thanks to their proliferation and differentiation capacity, these cells are considered an invaluable therapeutic option to treat a wide group of diseases caused by acute or chronic tissue degeneration. The clinical trials developed to date, suggest that these cells, produced under ideal conditions, are a safe therapeutic option that could mean a substantial improvement in patients’ quality of life, suffering from medical conditions caused by degeneration in tissues as varied as the skin, articular and meniscal cartilage, bone, ligament structures, and muscle, including myocardium.

These cells must be produced under ideal conditions, that allows to account of their identity, functional characteristics, and safety, thus boosting their therapeutic capacity for the benefit of the patients.

Therapeutic capacity of MSCs

Their therapeutic effectiveness has been consistently shown both in clinical models and preclinical ones. The results of all of these experiments suggest that the therapeutic capacity of these cells, depends not only on their capacity to replace lost cells in diseased tissues, distinguishing towards the respective tissue lineages. It has also been proved that their therapeutic capacity correlates with his capacity to modulate other tissue processes related to the health-disease process, such as neovascularization, the modification of the extracellular matrix, and the immune system functioning as a result of the biological effect of the molecules released by them.

Capacity of these cells

It is accepted that they have the capacity to modulate the activity of the immune system favoring the development of processes that facilitate the tissue regeneration. For example, it has been proved that these cells have the capacity to induce the production of M2 monocytes, besides restraining the activity of T helper (Th) lymphocytes, natural killing cells (NK), and dendritic cells, which have a direct effect on the clinical condition of patients with autoimmune disorders, but also with the development of biological processes indispensable for the general regeneration of tissue, including the neovascularization, reorganization of the extracellular matrix, and activation of the tissue stem cells.

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